COVID-19 is an emerging, rapidly evolving situation. A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia. Consult your … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is given by injection into a vein.. Common side effects include nausea, diarrhea, … Meropenem-induced pancytopenia in a preterm neonate: a case report. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Immune thrombocytopenia (ITP) is a commonest blood disorder that causes thrombocytopenia or low platelet count. Call your doctor for medical advice about side effects. Liu J, Liu Y, Liu S, Zhang Q, Zheng J, Niu Y, Wang X. Burns Trauma. 1. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. These side effects may go away during treatment as your body adjusts to the medicine. Side Effects; Download; About; Search results : Meropenem. Meropenem is one of the most commonly used antibacterial agents with relatively few side effects. Along with its needed effects, meropenem may cause some unwanted effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. It was also noted that prevalence of side effects increased when meropenem was prescribed in renal compromised patients, and also observed that generalized health of patients decreased with meronem use in renal unstable patients. Case report: The IV LD 50 of meropenem in rodents is greater than 2000 mg/kg. MAIPA experiments demonstrated that glycoprotein IIb/IIIa was the binding site of the meropenem-induced PLT antibodies. What is thrombocytopenia ? We report, using a randomized trial, the potential of antimicrobials to induce thrombocytopenia. Drug‐induced platelet (PLT) antibodies were detected by enzyme immunoassay, flow cytometry, and monoclonal antibody … Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Drug utilization evaluation of meropenem and correlation of side effects with renal status 1504 Pak. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. Prevention and treatment information (HHS). In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in … Background: Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Common side effects of meropenem include diarrhea, nausea and vomiting, and headache. Side effects not requiring immediate medical attention Constipation redness and swelling at the injection site This phase IV clinical study is created by eHealthMe based on reports of 40 people who have side effects when taking Meropenem from sources other than the FDA, … Meropenem is generally well tolerated by the central nervous system. Jatzlauk G, Althaus K, Strobel U, Kiefel V, Wesche J, Muehlenberg K, Greinacher A, Bakchoul T. Transfusion. Meropenem for injection (I.V.) Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. Anemia If experienced, these tend to have a Less Severe expression 1. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Crit Care Med 30 (2002): 2580-3, 20. Conclusions: 2019 Apr 26;7:13. doi: 10.1186/s41038-019-0150-7. The drug is generally well tolerated, but children may be more prone to adverse effects. Some drugs like anticancer drugs and valproic acid causes dose depended decrease in the number of platelets by myelosuppression. Paquet P, Jacob E, Damas P, Pierard GE "Recurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability." O 0, 13. J Antimicrob Chemother 24(suppl a (1989): 311-20, 9. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." •Conclusion: A regimen of 500mg IV q6h is able to achieve a similar probability of target attainment with Experts have previously told Newsweek that rare side-effects may emerge as the vaccines are rolled out across large populations, but the benefits far outweigh the risks. Clin Ther 28 (2006): 1164-74, 12. [Determination of platelet-associate autoantibodies against platelet-specific receptors by cytometric bead array and its clinical application in idiopathic thrombocytopenic purpura]. Seizures and other adverse CNS experiences have been reported. Approximately half of the patients admitted to the Intensive Care Unit (ICU) have been reported to have thrombocytopenia [1-3] and the condition is associated with prolonged hospitalization and reduced survival rates [].Thrombocytopenia is often caused by severe sepsis or septic shock … The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. COPD Study Group." Meropenem is generally well tolerated by the central nervous system. Am J Health Syst Pharm 69 (2012): 1109, 19. After other causes were ruled out, DITP was suspected. Last updated on Oct 21, 2020. NIH RH and GQC contributed equally to this work and should be considered co‐first authors. Meropenem‐induced immune thrombocytopenia and the diagnostic process of laboratory testing. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Zeneca Pharmaceuticals, Wilmington, DE. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM. Seizures occurred more often in patients with moderately severe renal dysfunction. J. Pharm. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." A 59-year-old male patient developed severe thrombocytopenia 8 days after the administration of meropenem and cefoperazone-sulbactam. Serious adverse reactions reported with meropenem are rare with an incidence of 1 %. Meropenem is one of the most commonly used antibacterial agents with relatively few side effects. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Zhanel GG, Wiebe R, Dilay L, et al. Flucloxacillin-induced immune thrombocytopenia. J01D H02 (Meropenem) ... Probenecid konkurrerer med meropenem om aktiv tubulær sekresjon, og hemmer dermed nyreutskillelsen av meropenem, som gir økt t 1 / 2 og … A 59‐year‐old male patient developed severe thrombocytopenia 8 days after the administration of meropenem and cefoperazone‐sulbactam. Azuno Y, Yaga K, Sasayama T, Kimoto K. Thrombocytopenia induced by Jui, a traditional Chinese herbal medicine. Some side effects may not be reported. Like a does meropenem cause thrombocytopenia fire cool blood stop nosebleed vomiting blood by enhance quality of capillaries as co-enzymes. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. 2016 Jan;56(1):67-72. doi: 10.1111/trf.13284. J Antimicrob Chemother 36(suppl a (1995): 145-56, 14. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others.  |  Our Vabomere (meropenem and vaborbactam) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Drugs 67 (2007): 1027-1052, 4. 2006 May;17(3):143-8. doi: 10.1080/09537100500437950. Infection 24 (1996): 473-9, 8. amoxicillin, doxycycline, metronidazole, azithromycin, triamcinolone, cephalexin, ciprofloxacin, clindamycin, Augmentin, levofloxacin. Clin Infect Dis 24 ( Suppl (1997): s222-30, 10. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Epub 2015 Sep 1. There was pancytopenia … The adverse reactions include rashes, headache, thrombocytopenia, altered liver function, nausea and vomiting. "Product Information. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. eCollection 2019.  |  More information: STITCH, PubChem (stereo-specific compound: 1) and possibly Wikipedia. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. Meropenem Fresenius Kabi. Merrem IV (meropenem injection) is an antibiotic used to treat bacterial infections, including E. coli, H. influenzae, pneumonia, bacterial meningitis, and others. is indicated for the treatment of complicated skin and skin structure infections (cSSSI) due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides … If experienced, these tend to have a Severe expression 1. 1. Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients. Clinicians should be cognizant of DITP, and a definitive diagnosis should be pursued, if feasible. Cerner Multum, Inc. "Australian Product Information." Would you like email updates of new search results? They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Clin Infect Dis 36 (2003): E149-E151. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." Antimicrob Agents Chemother 42 (1998): 1233-8, 6. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. Hussain K, Salat MS, Mohammad N, Mughal A, Idrees S, Iqbal J, Ambreen G. J Med Case Rep. 2021 Jan 29;15(1):25. doi: 10.1186/s13256-020-02632-1. HHS Side Effects for MERREM IV (meropenem injection) are also known as adverse reactions. Side effects . Options: Hide MedDRA Preferred Terms. Liu XG, Wang YM, Hou M, Zhang T, Zhu YY, Peng J. Zhonghua Xue Ye Xue Za Zhi. Several antimicrobials have been implicated, although experimental evidence to demonstrate causality is limited. Medically reviewed by Drugs.com. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in … Headache 5. Diarrhea 4. O 0, 3. Although not all of these side effects may occur, if they do occur they may need medical attention. Patients who are hypersensitive to penicillins may also be hypersensitive to meropenem.  |  Introduction. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 15. USA.gov. Do not drive or operate heavy machinery until you know how meropenem affects you.

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