Medicine (Baltimore). Following its initial description in children by George Still ... Chang RW, Dwosh I, et al. Objectives: To validate the Fautrel classification criteria for adult-onset Still's disease (AOSD) and to compare the discriminative performance to that of the Yamaguchi criteria. Disease can be monocyclic - self limiting, polycyclic - symptoms recur or have chronic articular pattern Case reports. More importantly, reactive hemophagocytic syndrome may occur in patients. Methods: We retrospectively reviewed the medical charts of 426 patients who had serum ferritin level and percentage glycosylated ferritin assayed at the biochemistry laboratory of Bichat Hospital. Adult-onset Still’s disease (AOSD) is a rare, systemic, inflammatory disorder of unknown etiology with an estimated incidence of 0.14–0.40 cases per 100,000 people and a prevalence of 1–34 cases per million people [1, 2].It affects young adults, with a higher prevalence in women [2–4] and most commonly presents with high daily spiking fever, arthritis and … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. It often mimics malignant lymphoma, and immunohistochemical and molecular studies are needed for definite diagnosis.  |  This is the most common cause of uveitis in children. Arthritis Rheum 1992; 35:498. eCollection 2020. More importantly, reactive hemophagocytic syndrome may occur in patients. This  |  Cited Here [4]. Rheumatoid arthritis (RA) is a connective tissue disorder resulting in an inflammatory arthritis. Major criteria: Fever of at least 39°C lasting at … 2020 Dec 11;99(50):e23579. We reported a case-series of 5 patients who presented features of both diseases. Cush criteria for classification of Still's disease Requires all of the following: Fever > 39 degrees Arthralgia and/or arthritis Rheumatoid factor < 1:80 Anti Nuclear Antibodies < 1:100 In addition, any two of the following is sited for: WBC count > 15,000 Stills rash Pleuritis or Pericarditis Hepatomegaly, Splenomegaly, or Lymphadenopathy 11. CRP), leukocytosis, thrombocytosis and elevated ferritin (an acute phase protein) are common 2008 Sep;67(5):415-22; quiz 423. doi: 10.1007/s00393-008-0325-2. Chronic Uveitis is defined as a persistent uveitis characterized with prompt relapse in less than 3 months after discontinuation of therapy. While it is unusual for RA to present with skin problems, cutaneous features are not uncommon. Diagnostic criteria for adult onset Still’s disease (AOSD) Yamaguchi’s criteria (Yamaguchi M. et al., . J Rheumatol 1992;19:424–30. Front Immunol. A total of 57 patients, among them 30 women, were diagnosed. Presentation and diagnosis of adult-onset Still's disease: the implications of current and emerging markers in overcoming the diagnostic challenge. Copyright © 2021 Elsevier B.V. or its licensors or contributors. In this review we attempt to place this syndrome in perspective, including data on geoepidemiology, clinical and laboratory features. 2019 Jan 10;6(1):001023. doi: 10.12890/2019_001023. doi: 10.1097/MD.0000000000023579. This disambiguation page lists articles associated with the title Still's disease. Other names: Adult Still's Disease; Adult-Onset Still Disease. The Yamaguchi criteria require the presence of five features, with at least two being major diagnostic criteria. https://doi.org/10.1016/j.jaut.2014.01.011. All met the preliminary criteria for a classification of adult Still’s disease proposed by Yamaguchi et al.6 Briefly, five or more criteria were required for diagnosis, including two or more major criteria: fever (39°C or higher), arthralgia (lasting more than two weeks), typical rash, and leucocytosis with granulocytosis; minor criteria include sore throat, lymphadenopathy and/or splenomegaly, liver dysfunction, and negative rheumatoid factor/antinuclear antibodies.

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